gene_symbol
CCR4
hgnc_id
HGNC:1605
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CCR4 on target cells and engages FcγRIIIa on NK cells (enhanced by defucosylation), inducing strong ADCC that lyses CCR4+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
GPCR expressed on malignant T cells and Tregs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05956041
disease_id_num_tar_ref
1494
drug_id_num_tar_ref
4034