gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TILs recognize the patient-specific neoantigen peptide presented on HLA class I via their native TCRs and directly kill target cells through perforin/granzyme-mediated apoptosis (and Fas–FasL), with additional cytokine-driven cytotoxic effects.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC class I complex recognized by CD8+ TIL TCR; HLA allele–restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06530303
disease_id_num_tar_ref
1498
drug_id_num_tar_ref
4045