gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells, inducing direct caspase-independent cell death and engaging FcγRIIIa on effector cells to drive ADCC and phagocytosis (with some complement activity), depleting CD20+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II anti-CD20 binding; induces direct B-cell death and enhances ADCC/ADCP
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427213
disease_id_num_tar_ref
1515
drug_id_num_tar_ref
4092