gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its afucosylated Fc engages FcγRIIIa (CD16a) on NK cells/macrophages to trigger ADCC/ADCP, killing CD20+ B cells (and also inducing direct B‑cell death). CD16a-expressing cells are effectors, not targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Afucosylated Fc enhances affinity and ADCC via NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06427213
disease_id_num_tar_ref
1515
drug_id_num_tar_ref
4092