gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Selective inhibition of HER2 kinase blocks autophosphorylation and MAPK/PI3K-AKT signaling, causing growth arrest and apoptosis of HER2-dependent tumor cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds HER2 kinase domain (ATP site); selective tyrosine-kinase inhibitor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06067776
disease_id_num_tar_ref
1517
drug_id_num_tar_ref
4100