gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-HER2 ADC binds HER2, is internalized, and a cleavable linker releases the DXd topoisomerase I inhibitor that induces DNA damage and cell death (with additional ADCC and bystander effects).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain (trastuzumab epitope; subdomain IV)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06088056
disease_id_num_tar_ref
1519
drug_id_num_tar_ref
4104