gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binding to HER2 recruits FcγR-expressing immune cells to mediate ADCC (and possibly complement-mediated lysis), killing HER2+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain subdomain IV; blocks dimerization and triggers ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06770296
disease_id_num_tar_ref
1521
drug_id_num_tar_ref
4108