gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases deruxtecan (DXd), a topoisomerase I inhibitor, causing DNA damage and apoptosis in the target cell; the membrane-permeable payload can also kill nearby cells (bystander effect).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase; extracellular domain binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06504719
disease_id_num_tar_ref
1522
drug_id_num_tar_ref
4110