gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds TROP-2 on tumor cells and delivers SN-38 (topoisomerase I inhibitor) via internalization or local release, causing DNA damage and apoptosis; also enables bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface antigen targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06504719
disease_id_num_tar_ref
1522
drug_id_num_tar_ref
4111