gene_symbol
CD28
hgnc_id
HGNC:1653
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The bispecific antibody bridges CD28 on T cells with EGFR on tumor cells to deliver localized CD28 costimulation, boosting T‑cell–mediated killing of EGFR-positive tumor cells (perforin/granzyme, cytokines); CD28-expressing T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Conditional agonist; CD28 costimulation is activated only when antibody is co-engaged with EGFR on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05983133
disease_id_num_tar_ref
1528
drug_id_num_tar_ref
4124