gene_symbol
CD5
hgnc_id
HGNC:1685
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD5-specific CAR on engineered NK cells binds CD5 on target cells, triggering NK degranulation (perforin/granzyme-mediated cytolysis and apoptosis) leading to direct killing of CD5+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR target antigen on malignant T cells and some B-cell tumors
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05110742
disease_id_num_tar_ref
1534
drug_id_num_tar_ref
4142