gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD122 is not the CAR target. IL-15 produced by the engineered NK cells signals through CD122 to enhance NK survival/persistence, while cytotoxicity is directed by the CD5 CAR to kill CD5+ malignant lymphocytes.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by constitutively expressed IL-15 to support NK survival/persistence
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05110742
disease_id_num_tar_ref
1534
drug_id_num_tar_ref
4142