gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
These CAR-NK cells target CD5, not CD132. They kill CD5+ cells via CAR-triggered NK cytotoxicity (perforin/granzyme). CD132 functions in IL-15/IL-2 receptor signaling to support NK survival and is not a cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of the IL-15 receptor complex engaged by IL-15 on engineered NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05110742
disease_id_num_tar_ref
1534
drug_id_num_tar_ref
4142