gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti-EGFR antibody blocks EGFR signaling and engages FcγR-bearing effector cells (e.g., NK cells, macrophages) to mediate ADCC, killing EGFR+ cells; may also trigger some CDC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (EGF-binding region, domain III) to block ligand binding and receptor activation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06389760
disease_id_num_tar_ref
1538
drug_id_num_tar_ref
4154