gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Bispecific CAR-T cells co-recognize CLDN18.2 and NKG2D ligands on tumor cells, activating CAR signaling and inducing contact-dependent killing via perforin/granzyme release and cytokine-mediated cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform of claudin-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06134960
disease_id_num_tar_ref
1540
drug_id_num_tar_ref
4163