gene_symbol
ULBP5
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
KD-496 CAR T cells recognize ULBP5 (an NKG2D ligand) together with CLDN18.2 on the same cell, activating CAR signaling and T-cell degranulation (perforin/granzymes) to lyse the target cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
NKG2D ligand
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06134960
disease_id_num_tar_ref
1540
drug_id_num_tar_ref
4163