gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-binding ADC is internalized and releases MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptosis; Fc-mediated ADCC may also contribute.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05627414
disease_id_num_tar_ref
1548
drug_id_num_tar_ref
4180