gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HER2-targeted ADC binds HER2, is internalized, then releases MMAE, which binds beta-tubulin and inhibits microtubule polymerization, causing G2/M arrest and apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload (MMAE) target; binds Vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05627414
disease_id_num_tar_ref
1548
drug_id_num_tar_ref
4180