gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HMBD-001 binds HER3 on target cells and its IgG1 Fc engages CD16A on NK cells to trigger ADCC, killing HER3-expressing cells. CD16A-expressing cells are effectors, not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADCC effector engagement via IgG1 Fc
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05910827
disease_id_num_tar_ref
1551
drug_id_num_tar_ref
4188