gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CD19, is internalized, and releases a PBD dimer that forms DNA interstrand cross-links (minor groove, N2 of guanine), blocking replication and killing the CD19+ cell.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface B-cell antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05991388
disease_id_num_tar_ref
177
drug_id_num_tar_ref
481