gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the NY-ESO-1 peptide presented by HLA-A2 and kill target cells via TCR-triggered perforin/granzyme-mediated cytotoxicity (apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted peptide–MHC target for the engineered TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05881525
disease_id_num_tar_ref
1561
drug_id_num_tar_ref
4224