gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Vaccine primes TAA-specific CD8+ T cells; CTLs kill tumor cells presenting TAA-derived peptides on HLA-A2 via perforin/granzyme cytolysis. HLA-A2 itself is not the cytotoxic target.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-MHC class I binding on dendritic cells; HLA-A2 restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05589597
disease_id_num_tar_ref
1565
drug_id_num_tar_ref
4234