gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
IgG1 anti‑EGFR antibody binds EGFR on tumor cells and its Fc engages Fcγ receptors on immune effectors (e.g., NK cells) to trigger ADCC, killing EGFR+ cells; EGFR blockade mainly inhibits proliferation.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular (ligand-binding) domain
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06490341
disease_id_num_tar_ref
1569
drug_id_num_tar_ref
4248