gene_symbol
CALR
hgnc_id
HGNC:1455
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The peptide vaccine elicits CALR-mutant–specific CD8+ T cells; these CTLs recognize the mutant CALR peptide on MHC I of target cells and kill them via perforin/granzyme (and Fas–FasL) pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Shared 36-aa mutant C-terminus generated by exon 9 CALR frameshift mutations; presented on MHC class I/II
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05025488
disease_id_num_tar_ref
1574
drug_id_num_tar_ref
4264