gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes CALR-mutant–specific cytotoxic T cells that kill CALR-mutant malignant cells via TCR recognition and perforin/granzyme pathways. A KLH helper peptide, if present, only provides CD4 T-cell help and is not a cytotoxic target, so cells expressing KLH are not killed.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Helper peptide included to enhance T-cell help and vaccine immunogenicity
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05025488
disease_id_num_tar_ref
1574
drug_id_num_tar_ref
4264