gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
IgG1 Fc is on antibodies, not cell surfaces. CD19 t-haNK kills CD19+ cells via CAR and can mediate ADCC when cells are opsonized by IgG1 antibodies, but it does not target IgG1 Fc on cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc region of therapeutic antibodies enabling ADCC (e.g., rituximab)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06334991
disease_id_num_tar_ref
1585
drug_id_num_tar_ref
4292