gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The bispecific antibody binds EGFR on tumor cells and delivers actinium‑225 alpha radiation, causing high‑LET DNA double‑strand breaks and lethal damage (apoptosis/necrosis) without requiring immune-cell engagement.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
binds extracellular domain of a receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06147037
disease_id_num_tar_ref
178
drug_id_num_tar_ref
491