gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blocks the CD47–SIRPα inhibitory checkpoint on tumor cells, enabling macrophage activation and phagocytosis (ADCP) to clear CD47-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
SIRPα ligand; innate immune checkpoint 'don't-eat-me' signal
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05626322
disease_id_num_tar_ref
1609
drug_id_num_tar_ref
4359