gene_symbol
MET
hgnc_id
HGNC:7029
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
A bispecific anti-EGFR/c-MET antibody conjugated to actinium-225 binds c-MET on target cells and delivers high-LET alpha radiation, causing DNA double-strand breaks and apoptotic tumor cell death without immune cell mediation.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
binds extracellular domain of a receptor tyrosine kinase
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06147037
disease_id_num_tar_ref
178
drug_id_num_tar_ref
491