gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Tafasitamab binds CD19 on B cells; its Fc engages Fcγ receptors (including CD64) on effector cells to trigger ADCC/ADCP that kills CD19+ B cells. CD64+ cells are effectors, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated binding; high-affinity receptor on monocytes/macrophages
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05626322
disease_id_num_tar_ref
1609
drug_id_num_tar_ref
4360