gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells and bridges them to allogeneic gamma delta T cells, which form an immune synapse and kill the CD20+ cells via MHC-independent perforin/granzyme-mediated cytotoxicity (with IFN-γ secretion).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Targeted via rituximab-conjugated gdT cells using DNA linkers
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05653271
disease_id_num_tar_ref
1625
drug_id_num_tar_ref
4395