gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti‑FRα antibody–drug conjugate binds FRα, is internalized, and releases the DM4 payload that inhibits tubulin polymerization, leading to mitotic arrest and apoptosis (with possible local bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface GPI-anchored receptor; antibody component binds and internalizes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06390995
disease_id_num_tar_ref
1630
drug_id_num_tar_ref
4411