gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds TROP2, is internalized, and releases SN-38 intracellularly; SN-38 inhibits topoisomerase I, causing DNA damage, replication arrest, and apoptosis (with a hydrolyzable linker allowing some bystander killing).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Recognized by hRS7 antibody component of ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05552001
disease_id_num_tar_ref
1633
drug_id_num_tar_ref
4414