gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds Trop-2 (not TOP1), is internalized, and releases SN-38, which inhibits TOP1 to cause DNA damage and apoptosis. TOP1 is the intracellular enzymatic substrate of the payload, not the recognition target that directs killing.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibited by SN-38 payload; stabilizes TOP1–DNA covalent complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05552001
disease_id_num_tar_ref
1633
drug_id_num_tar_ref
4414