gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Glofitamab binds CD3 on T cells and CD20 on B cells, crosslinking and activating T cells to kill CD20+ cells via perforin/granzyme release; CD3E+ T cells are not the cytotoxic targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell CD3 component targeted to redirect T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06651853
disease_id_num_tar_ref
1640
drug_id_num_tar_ref
4437