gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
A-319 engages CD3 on T cells to activate and redirect them to kill CD19+ B cells; CD3ε-expressing T cells are not killed but mediate perforin/granzyme-dependent cytotoxicity against CD19+ targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell receptor-CD3 complex subunit on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06400537
disease_id_num_tar_ref
182
drug_id_num_tar_ref
499