gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Blinatumomab binds CD3ε on T cells to activate them; these T cells then kill CD19+ B cells via perforin/granzyme release. CD3ε-expressing T cells are not targeted for killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Part of the TCR-CD3 complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06649422
disease_id_num_tar_ref
1651
drug_id_num_tar_ref
4465