gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds BCMA on target cells, is internalized, and releases MMAF, which binds beta‑tubulin to disrupt microtubules and kill BCMA+ cells; beta‑tubulin itself is not the antigen targeted by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAF payload binds the vinca site to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05714839
disease_id_num_tar_ref
1658
drug_id_num_tar_ref
4484