gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Belantamab mafodotin targets BCMA, not Fc gamma receptor IIa (CD32a). Its afucosylated IgG1 Fc engages CD32a on immune effector cells to drive ADCC/ADCP against BCMA+ cells, and the MMAF payload kills BCMA-expressing cells after internalization; CD32a+ cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated ADCP engagement on myeloid cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05714839
disease_id_num_tar_ref
1658
drug_id_num_tar_ref
4484