gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and its Fc engages Fcγ receptor–bearing effector cells (e.g., NK cells) to mediate ADCC against HER2+ cells; may also trigger complement (CDC).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV of the HER2 receptor
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05715931
disease_id_num_tar_ref
1660
drug_id_num_tar_ref
4487