gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells; its Fc engages Fcγ receptors (including CD32A) on effector cells to mediate ADCC and CDC, killing CD20+ B cells. Cells expressing CD32A are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Effector interaction via IgG1 Fc (mediates ADCP/ADCC)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04680962
disease_id_num_tar_ref
1672
drug_id_num_tar_ref
4518