gene_symbol
C1QA
hgnc_id
HGNC:1241
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MabThera binds CD20 on B cells and recruits C1q to its Fc to initiate complement-dependent cytotoxicity against CD20+ cells; cells expressing C1q are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds IgG1 Fc to initiate CDC; entry represents the C1q complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04680962
disease_id_num_tar_ref
1672
drug_id_num_tar_ref
4518