gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD19 CAR T cells bind CD19 on B cells, become activated via CD3ζ/4-1BB signaling, and directly kill target cells through perforin/granzyme-mediated lysis and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
FMC63-derived scFv; extracellular antigen; HLA-independent
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06458439
disease_id_num_tar_ref
186
drug_id_num_tar_ref
509