gene_symbol
FCGR2B
hgnc_id
HGNC:3618
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Rituximab targets CD20, not FcγRIIb (CD32B). Killing occurs when cells express CD20 via ADCC, CDC, and apoptosis; CD32B expression itself does not trigger cytotoxicity (cells are affected only if they also express CD20).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Inhibitory FcγR; crosslinking can modulate B-cell signaling/apoptosis
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04680962
disease_id_num_tar_ref
1672
drug_id_num_tar_ref
4519