gene_symbol
C1QA
hgnc_id
HGNC:1241
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Rituximab targets CD20 on B cells; its Fc binds C1q to activate complement, leading to CDC (and ADCC/apoptosis) of CD20+ cells. C1q is not the antigen, so C1q-expressing cells are not directly targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds IgG1 Fc to initiate classical complement pathway (C1q complex includes A/B/C chains)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04680962
disease_id_num_tar_ref
1672
drug_id_num_tar_ref
4519