gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells and engages Fcγ receptor–bearing effector cells (e.g., NK cells, macrophages) to mediate ADCC, leading to perforin/granzyme-dependent killing; may also contribute some CDC and growth inhibition via HER2 blockade.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain IV epitope to inhibit signaling and promote ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06068985
disease_id_num_tar_ref
1677
drug_id_num_tar_ref
4530