gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 on tumor cells; its Fc engages CD16A on NK cells to trigger ADCC that kills HER2-positive cells. CD16A-expressing effector cells are not targeted or killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IgG1 Fc-mediated engagement on NK cells to trigger ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06068985
disease_id_num_tar_ref
1677
drug_id_num_tar_ref
4530