gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Trastuzumab binds HER2 and is internalized; intracellular release of the DM1 payload inhibits microtubules, causing mitotic arrest and apoptosis. The Fc can also mediate ADCC.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds domain IV on HER2, enabling internalization and ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06068985
disease_id_num_tar_ref
1677
drug_id_num_tar_ref
4531