gene_symbol
CD22
hgnc_id
HGNC:1643
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD22 ADC binds CD22, is internalized, and releases calicheamicin intracellularly; the payload binds DNA’s minor groove, causes double‑strand breaks, and triggers apoptosis.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC target antigen on B cells; internalization enables payload delivery
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05645718
disease_id_num_tar_ref
1679
drug_id_num_tar_ref
4540