gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Benralizumab targets IL-5Rα on eosinophils; its afucosylated Fc engages CD16a on NK cells to drive ADCC against IL-5Rα+ cells. CD16a-expressing cells (NK cells) are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc engagement on NK cells; afucosylated IgG1 Fc increases affinity to drive potent ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05528913
disease_id_num_tar_ref
1687
drug_id_num_tar_ref
4568